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. 2013 Dec 3;8(12):e81900. doi: 10.1371/journal.pone.0081900

Figure 4. CpG island methylation in the αA-crystallin promoter was significantly greater in high-myopic cataracts than in age-related cataracts classified as Lens Opacity Classification System III Grade Nuclear Color 5–6.

Figure 4

(A) Representative pyrosequencing results of the Age-Related Cataract (ARC) Nuclear Color (NC) 5–6 and High-Myopic Cataract (HMC) NC5–6 Groups. (B) Anterior segment photos of patients in each group. (C) The six selected CpG islands in the HMC NC5–6 Group (57.6±2.6%) displayed hypermethylation compared with the ARC NC5–6 Group (48.1±3.4%). (D) Percentage of methylation at each individual CpG site in each group. (*Statistically significant differences were found between the ARC NC5–6 and HMC NC5–6 Groups; *all p<0.05).