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. 2013 Sep 16;10:99. doi: 10.1186/1742-4690-10-99

Figure 8.

Figure 8

The immune response to the MPER HIV-1 insert. Five out of six macaques in group 3 (A) and in group 1 (B) produced high-titered antibodies in response to the MPER insert. One animal showed a moderate response. The sera were tested four to seven weeks after immunization with replicating vectors in group 3 macaques and four weeks after live rubella vectors in group 1. The empty rubella vaccine control (CL6A) elicited no antibodies, indicating specificity for the insert. No binding to gp120 was observed in any serum, indicating antibody specificity for the MPER insert. However, the group 1 antibodies did not bind monomeric MPER peptides corresponding to the 2F5 and 4E10 epitopes, and similar results were obtained with group 3 antibodies.