Figure 9.

Persistence of anti-rubella and anti-Gag antibodies elicited by rubella vectors in group 3 macaques. The midpoint titers of anti-rubella antibodies (A, C, E) and anti-Gag antibodies (B, D, F) were measured for each animal between weeks 22 to 56 of the study, corresponding to weeks 4 to 38 after rubella immunization. Both antibodies peaked by 4 to 7 weeks after immunization. For DCVV, the decline in rubella antibodies and anti-Gag antibodies were both less than 3-fold over 34 weeks. For CL49, anti-Gag antibodies declined about 3-fold, while the decline in rubella antibodies was much greater. For CL67, anti-Gag antibodies declined about 13 -fold, which was greater than the decline in anti-rubella titers.