Figure 5.

Electron micrographs from transverse sections of sciatic nerves of Lmna knockout and control mice at age 7 wks. A, Sciatic nerve of Lmna +/+ control. B, Sciatic nerve of Lmna +/− mouse. No abnormality was detected, although a slight accumulation of neurofilaments was observed. Axon density, size, and myelination were preserved. C, Sciatic nerve of Lmna −/− mouse. Axon density was reduced, and several pathological axons are indicated by asterisks (*). The axons' diameters are enlarged, and no myelin sheath is visible; additionally, they present focal accumulations of neurofilaments, as observed in nerves of Lmna +/− mouse (bars correspond to 1 μm).