Table 3.
Allele Frequencies of Four MTHFR Polymorphisms Associated with the 677C and 677T Alleles in White and Japanese Individuals Homozygous for these Alleles
|
Allele Frequency (95% CI) inb |
|||||
| Whites |
Japanese |
||||
| Location | Nucleotide Polymorphisma | 677C(N=262) | 677T(N=404) | 677C(N=50) | 677T(N=82) |
| Intron 2 | 533 G→A |
.54 (.47–.60) | .998 (.987–.999) | .79 (.65–.90) | 1.00 (.95–1.00) |
| Intron 6 | 31 C→T |
.32 (.26–.38) | .979 (.96–.99) | .60 (.45–.74) | .95 (.88–.99) |
| Exon 7 | 1298 A→C |
.52 (.46–.58) | .998 (.987–.999) | .64 (.49–.77) | .988 (.93–.999) |
| Intron 10 | 262 C→G |
.57 (.50–.63) | .997 (.987–.999) | .76 (.62–.87) | .95 (.88–.99) |
a
Underlined bases denote the alleles for which the frequency is given.
b
N denotes the number of alleles examined. Differences in allele frequencies within each population are significant at P<.0001, with the exception of the intron-10 262C→G polymorphism in the Japanese population, for which P=.0018.