Table 4.
Frequency Distribution of Haplotypes in MTHFR 677C and 677T Alleles
|
Haplotype Frequency ± SD inb |
||||||
| Whites |
Japanese |
Africans |
||||
| Haplotypea | 677C(N=250) | 677T(N=126) | 677C(N=95) | 677T(N=69) | 677C(N=319) | 677T(N=29) |
| G-T-A-C | .255±.04 | .984±.106 | .66±.09 | .97±.13 | .30±.03 | 1.00±.31 |
| A-C-C-G | .43±.04 | 0 | .17±.06 | 0 | 0 | 0 |
| A-C-A-C | .02±.01 | 0 | 0 | 0 | .30±.03 | 0 |
| G-C-A-C | .075±.025 | .016±.016 | .04±.03 | .03±.03 | .27±.03 | 0 |
| A-C-A-G | .06±.02 | 0 | 0 | 0 | 0 | 0 |
| G-C-C-G | .06±.02 | 0 | 0 | 0 | .02±.01 | 0 |
| G-T-C-C | .02±.01 | 0 | 0 | 0 | 0 | 0 |
| A-C-C-C | .01±.01 | 0 | .09±.04 | 0 | 0 | 0 |
| G-C-C-C | .035±.016 | 0 | .04±.03 | 0 | .05±.016 | 0 |
| A-T-A-C | 0 | 0 | 0 | 0 | .04±.015 | 0 |
| G-C-A-G | 0 | 0 | 0 | 0 | .01±.007 | 0 |
| G-T-A-G | .035±.016 | 0 | 0 | 0 | 0 | 0 |
a
Each haplotype represents states at the four polymorphic sites: intron 2, intron 6, exon 7, and intron 10.
b
N denotes the number of alleles examined. Haplotype frequencies were estimated using the maximum-likelihood method as implemented by the Arlequin software package. Differences in frequencies within each population are significant at P<.0001.