Table 1.

Univariate analysis of the prognostic factors in the whole CRC population

		OS		RFS		SAR
Factor	Comparison	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)
MSI	MSI-H vs MSS	0.0002	0.45 (0.30,0.69)	< 0.0001	0.48 (0.34,0.68)	0.9643	0.99 (0.65,1.52)
Site	Left vs Right	0.3143	0.89 (0.72,1.11)	0.2123	1.13 (0.93,1.36)	<0.0001	0.59 (0.47, 0.73)
Grade	G3,4 vs G1,2	0.0018	1.63 (1.29,2.23)	0.0012	1.56 (1.19,2.04)	0.0387	1.38 (1.01,1.88)
T stage	T3 vs T1,2	0.0634	1.76 (0.96,3.22)	0.0629	1.58 (0.97,2.58)	0.1399	1.57 (0.86,2.88)
	T4 vs T1,2	0.0002	3.06 (1.63,5.74)	< 0.0001	2.69 (1.61,4.48)	0.0680	1.78 (0.95,3.35)
N stage	N1 vs N0	< 0.0001	1.91 (1.38,2.65)	< 0.0001	1.78 (1.36, 2.32)	0.9809	0.98 (0.71,1.35)
	N2 vs N0	< 0.0001	4.51 (3.28,6.21)	< 0.0001	4.06 (3.11,5.29)	0.1498	1.24 (0.90,1.71)
BRAF	BRAF mut vs WT2	0.0004	1.92 (1.33,2.78)	0.0832	1.35 (0.96,1.89)	< 0.0001	2.56 (1.75,3.70)
	BRAF mut vs BRAF wt	0.0009	1.78 (1.26,2.53)	0.1174	1.30 (0.94,1.81)	< 0.0001	2.48 (1.74,3.53)
KRAS	KRAS mut vs WT2	0.1461	1.20 (0.93,1.54)	0.4410	1.09 (0.88,1.33)	0.1755	1.18 (0.93,1.52)
	KRAS mut vs KRAS wt	0.4826	1.09 (0.86,1.37)	0.7245	1.04 (0.85,1.27)	0.7222	1.04 (0.82,1.32)