Table 4.
Clinical Features of 13 Sib Pairs Discordant for the PTP1B Genotype
|
Mean ± SEM Valuesfor Sibs |
||||
| Feature | Wild Type | 1484insG | OSD | Pa |
| Age (years) | 35.7 ± 2.6 | 36.1 ± 2.9 | 22.0 | NS |
| BMI (kg/m2) | 23.7 ± .88 | 26.3 ± 1.14 | 34.2 | .02 |
| Fasting plasma glucose (mg/dl) | 88.2 ± 1.16 | 88.2 ± 1.9 | .50 | NS |
| Fasting plasma insulin (mU/L) | 7.5 ± 1.0 | 7.8 ± .7 | 4.45 | NS |
| HOMAIR | 1.63 ± .2 | 1.72 ± .2 | 1.07 | NS |
| Fasting serum cholesterol:fasting serum HDL cholesterol ratio | 3.5 ± .3 | 4.35 ± .4 | 11.3 | .02 |
| Fasting serum triglycerides (mg/dl) | 92.4 ± 14.5 | 116.6 ± 16.6 | 315.0 | .03 |
| Systolic blood pressure (mm Hg) | 109.6 ± 4.2 | 113.4 ± 4.5 | 50.0 | NS |
| Diastolic blood pressure (mm Hg) | 73.3 ± 2.5 | 77.1 ± 2.8 | 50.0 | .05 |
a
NS = not significant.