Table 1.
Population Characteristics by Genotype Groupa
| Genotype |
|||
|---|---|---|---|
| R/R | Q/R | Q/Qe | |
| n | 972 | 121 | 4 |
| Age, y | 54 (14) | 53 (15) | 50–84 |
| Female sex, % (frequency) | 52% (505) | 54% (66) | 75% (3) |
| Current smoker,b % (frequency) | 8% (80) | 11% (13) | 0% (0) |
| BMI, kg/m2 | 27.8 (5.0) | 27.7 (4.6) | 23.2–30.0 |
| Height, cm | 165 (9) | 165 (9) | 153–165 |
| Weight, kg | 75.2 (14.1) | 75 (13) | 59–75 |
| LDL, mg/dLc | 132 (33) | 198 (49) | 169–323 |
| HDL, mg/dL | 58 (15) | 54 (15) | 40–65 |
| TG, mg/dL | 86 (50) | 87 (57) | 57–145 |
| Use of cholesterol-lowering drugs, % (frequency) | 4% (38) | 10% (12) | 50% (2) |
| Median CAC (Q1, Q3)d | 1.03 (0, 106) | 129 (1.03, 585) | 0–1998 |
| BMD, g/cm2 | |||
| Femoral neck | 0.825 (0.138) | 0.814 (0.132) | 0.612–0.707 |
| Lumbar spine | 0.950 (0.153) | 0.927 (0.141) | 0.730–0.938 |
| 1/3 radius | 0.756 (0.108) | 0.736 (0.103) | 0.506–0.757 |
| Whole body | 1.124 (0.117) | 1.106 (0.116) | 0.855–0.972 |
Abbreviations: Q1, quartile 1; Q3, quartile 3; TG, triglyceride.
a
Unless otherwise noted, mean and SD are presented.
b
All individuals reporting current smoking are males; in Amish culture, tobacco use among women is prohibited.
c
LDL values for Q/Q subjects were 169, 171, 245, and 323 mg/dL.
d
CAC measures were available in only 861 participants (R/R, n = 772; Q/R, n = 85; Q/Q, n = 4).
e
Ranges are shown for Q/Q genotype instead of mean and SD due to small sample size.