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Sequence of the 5′ flanking region of the human ADSL gene. Bases are numbered by reference to the ATG codon. The bold arrow indicates the start point of the initiation of transcription. Thin arrows indicate the start points of the different constructs used for luciferase assay. Potential binding sites for nuclear factors are underlined. The core sequence of the tandem NRF-2 sites are double-underlined. Base −49T within the −52/−44 NRF-2 site is indicated in boldface.
