Table 3.
Overview of surgical complications: comparison of neoadjuvant R(C)T with and without intensification to our results
| Subject | 30 day mortality (%) | Anastomotic leakage (%) | Operative revision of anastomotic leakage (%) | Perineal wound infection (%) | |
|---|---|---|---|---|---|
| Own results (n = 212) |
+/- intensified RCT |
0 / 1.9 |
26.6 / 9.7 |
20.3 / 6.5 |
42.2 / 18.8 |
| Sauer et al. [1] (n = 823) |
Pre/post-operative RCT |
0.7 / 1.3 |
11 / 12 |
|
10 / 8+ |
| Bosset et al. [20] (n = 1011) |
RT/RCT |
1.2 / 2.4 |
|
|
|
| Kapiteijn et al. [19] (n = 1861) |
+/- RT |
No difference |
No difference |
|
26 / 18 |
| Voelter et al. [8] (n = 33) |
Intensified RCT |
3 |
6 |
|
58 |
| Horisberger et al. [21] (n = 59) |
All patients / major/minor response to intensified RCT |
3.4 |
15.5 |
15.5 |
|
| 6.1 / 0 |
25.9 / 0 |
25.9 /0 |
|||
| Gollins et al. [14] (n = 46) |
Intensified RCT |
0 |
6.4 |
|
22.2§ |
| Aschele et al. [22] (n = 747) |
Intensified (Oxaliplatin)/"not intensified" RCT |
1 / 1 |
2 / 1 |
|
9 / 9& |
| Sato et al. [23] (n = 67) |
S-1 plus Irinotecan |
0 |
0 |
0 |
0 |
| Garlipp et al. [24] (n = 2085) |
+/- preoperative chemoradio-therapy |
|
12.4 / 12.7 |
5.5 / 7.5 |
|
| Fucini et al. [25] (n = 80) | +/- preoperative RCT | 2 / 0 | 14.8 / 9.1 |
+delayed healing, §wound dehiscence, &other complication/undetermined.