Figure 4.
Reduction of GABAA receptor-mediated inhibition facilitated LTP induction. A, LTP could not be induced by mTBS in a slice from a P25 rat prenatally treated with saline. B, Robust LTP was induced in another slice from the same brain as that in A, in the presence of a specific GABAA receptor antagonist SR95531 (“SR”) (0.5 μm). Error bars indicate SEM. C, Summary of results on LTP induction from all experiments similar to those shown in A and B for rats prenatally treated with saline (n = 6) or cocaine (n = 8). D, Cumulative percentage for the distribution of the LTP magnitude for the data set shown in C. *p < 0.0001, Kolmogorov–Smirnov test.