Table 7.

VRK2 as independent marker in univariate and multivariate survival analysis in high-grade astrocytomas

	Univariate analysis		Multivariate analysis
Parameter	HR (95% C.I.)	Pvalue	HR (95% C.I.)	Pvalue
VRK2 expression	1.80 (1.07 – 3.02)	0.025	2.10 (1.24 – 3.58)	0.006
Age (<60 vs. ≥ 60)	1.94 (1.15 – 3.26)	0.011	1.80 (1.06 – 3.05)	0.031
Treatment (Chemo + RT vs. RT alone vs. no treatment)	1.96 (1.22 – 3.15)	0.003	2.01 (1.22 – 3.30)	0.006

HR: hazard ratio. RT: Radiotherapy. Chemo: Chemotherapy.