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. 2013 Aug 21;14:254. doi: 10.1186/1471-2105-14-254

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Copyright © 2013 Esnaola et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Distribution of the Poisson-Tweedie shape parameter as function of the mean expression level. Estimated Poisson-Tweedie shape parameter a as function of the mean expression level for each gene. Red dashed lines indicate the value of a corresponding to each specific distribution within the Poisson-Tweedie family, denoted by Pois (Poisson), PIG (Poisson-Inverse Gaussian), NB (negative binomial), PA (Pólya-Aeppli) and NtA (Neyman type A). The right y-axis indicates the percentage of genes around specific a values bounded by dotted grey lines. Data from Pickrell [12]et al. (2010) are shown without any normalization (a), normalized with edgeR[2](b), and normalized with cqn[4](c).