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. 2002 May 17;71(1):180–186. doi: 10.1086/341327

Figure 5.

Figure 5

A, Schematic diagram of human JAG1, mouse Jag1, and Drosophila Delta and Serrate protein structures, and the locations of missense mutations identified in EGF-like domains of human JAG1 and in the second EGF-like domain of mouse Jag1. The arrows indicate C-terminal deletions of Delta and Serrate. Superscripts associated with mutations are as follows: a = missense mutation described in the present study; b = mutation described in a kindred segregating ToF and characteristic facies; c = mutations described in patients with AGS; d = mutation described in mouse Slalom mutant; e = mutation described in mouse Headturner mutant. SP = signal peptide; DSL = conserved domain shared by Delta, Serrate, and Lag2; CR = cysteine-rich region; TM = transmembrane domain; IC = intracellular domain. B, Alignment of the amino acid sequence of the first EGF-like domain of human JAG1 with the corresponding sequences of the first EGF-like domain of human JAG2, the second EGF-like domain of human JAG1, and those from other species. Note the first cysteine is conserved in all of the wild-type sequences.