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Inflammatory Mediators Affect to the Primary Afferent Neuron
| Bradykinin | Proteinase | PGE2 | TNF-α | IL-1β | |
|---|---|---|---|---|---|
|
| |||||
| Receptors | B1*, B2 | PAR1**, PAR2 PAR4** | EP1-EP4 | TNFR1 | IL-1R |
| TNFR2 | |||||
| Intracellular signaling | PKCε | PKA | PKA | p38 MAPK | P38 MAPK |
| PKCε | PKCε | PKCε | |||
| Biological action | TRPV1↑ | (PAR2) | TRPV1↑ | TRPV1↑ | TTX-r VGSC↑ |
| TRPA1↑ | TRPV1↑ | TTX-r VGSC↑ | TTX-r VGSC↑ | ||
| nav1.9↑ | TRPV4↑ | ||||
Inducible, does not exist in naive
anti-nociceptive. VGSC: Voltage-gated sodium
