Table II.

Association of phosphorylated extracellular-signal-regulated kinase 1 and 2 (p-ERK1/2) and cyclooxygenase 2 (COX2) expression with clinicopathological data for patients with esophageal cancer.

		p-ERK1/2			COX2
	N	High N (%)	Low N (%)	p Value	High N (%)	Low N (%)	p Value
Gender
M	69	14 (20)	55 (80)		30 (43)	39 (57)
F	21	3 (14)	18 (86)	0.75	8 (38)	13 (62)	0.80
Age (years)
≤ 55	25	2 (8)	23 (92)		8 (32)	17 (68)
> 55	65	15 (23)	50 (77)	0.13	30 (46)	35 (54)	0.24
Histological grade of tumor
I	7	3 (43)	4 (57)		2 (29)	5 (71)
II	61	10 (16)	51 (84)		21 (34)	40 (66)
III	22	4 (18)	18 (82)	0.24	15 (68)	7 (32)	0.016
TNM classification
I	6	2 (33)	4 (67)		3 (50)	3 (50)
II	62	8 (13)	54 (87)		28 (45)	34 (55)
III	9	3 (33)	6 (67)		3 (33)	6 (67)
IV	13	4 (31)	9 (69)	0.11	4 (31)	9 (69)	0.72
Clinical stage of disease
I	6	1 (17)	5 (83)		2 (33)	4 (67)
II	38	2 (5)	36 (95)		16 (42)	22 (58)
III	46	14 (30)	32 (70)	0.038	20 (43)	26 (57)	0.69
Smoking history
No	35	7 (20)	28 (80)		13 (37)	22 (63)
Yes	55	10 (18)	45 (82)	1.000	25 (45)	30 (55)	0.51
Alcohol use
No	30	6 (20)	24 (80)		14 (47)	16 (53)
Yes	60	11 (18)	49 (82)	1.000	24 (40)	36 (60)	0.65
Consumption of pickled food
No	52	6 (12)	46 (88)		19 (37)	33 (63)
Yes	38	11 (29)	27 (71)	0.055	19 (50)	19 (50)	0.28
Consumption of Hot drinks
No	73	10 (14)	63 (86)		33 (45)	40 (55)
Yes	17	7 (41)	10 (59)	0.016	5 (29)	12 (71)	0.28
Survival status
Alive	44	4 (9)	40 (91)		16 (36)	28 (64)
Dead	46	13 (28)	33 (72)	0.030	22 (48)	24 (52)	0.29