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. Author manuscript; available in PMC: 2015 Jan 1.

Published in final edited form as: Pediatr Blood Cancer. 2013 Sep 4;61(1):10.1002/pbc.24697. doi: 10.1002/pbc.24697

Table I.

Single Agent IC₅₀ of Olaparib and Cytotoxic Chemotherapy

Origin	Cell Line	IC₅₀ µM Mean (SD)
Origin	Cell Line	Olaparib	Irinotecan	SN-38	Melphalan	Doxorubicin	Carboplatin	Vincristine
Ewing Sarcoma	TC-71	1.5 (0.9)	0.5 (0.1)	0.004 (0.001)	3.2 (0.8)	0.018 (0.006)	3.9 (1.3)	0.006 (0.002)
Ewing Sarcoma	RD-ES	1.0 (0.3)	0.008 (0.002)	0.004 (0.001)	2.0 (0.6)	0.020 (0.007)	5.3 (1.8)	0.0012 (0.0004)
Medulloblastoma	HTB-185	2.1 (0.9)	0.8 (0.2)	0.005 (0.001)	2.2 (0.5)	0.019 (0.006)	2.7 (0.9)	0.004 (0.002)
Medulloblastoma	HTB-186	2.4 (0.7)	0.5 (0.1)	0.002 (0.001)	1.5 (0.4)	0.013 (0.004)	1.6 (0.6)	0.003 (0.001)
Neuroblastoma	SK-NAS	33.8 (8.7)	2.7 (0.5)	0.019 (0.005)	4.2 (1.0)	0.057 (0.008)	12.5 (3.8)	0.004 (0.001)
Neuroblastoma	NGP	2.5 (0.8)	1.0 (0.4)	0.003 (0.001)	1.7 (0.3)	0.010 (0.002)	9.2 (2.3)	0.0005 (0.0002)
Rhabdomyosarcoma	SJCRH-30	7.7 (2.3)	1.9 (0.3)	0.016 (0.005)	3.8 (0.9)	0.021 (0.006)	17.8 (3.0)	0.003 (0.001)
Rhabdomyosarcoma	RD	3.9 (1.3)	1.4 (0.5)	0.002 (0.001)	6.1 (1.3)	0.019 (0.008)	12.8 (2.8)	0.0017 (0.0003)
Osteosarcoma	HOS	19.6 (2.5)	1.6 (0.5)	0.008 (0.002)	5.2 (1.3)	0.016 (0.005)	4.9 (1.6)	0.006 (0.002)
Osteosarcoma	MG-63	4.7 (2.0)	1.5 (0.4)	0.013 (0.004)	2.0 (0.7)	0.035 (0.012)	9.9 (3.0)	0.002 (0.0004)
Breast Carcinoma	HCC-1937	≈100