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Effects of aging on mitochondrial RNA oxidation in skeletal muscle and liver. Levels of mtRNA increased significantly with age in (A) subsarcolemmal mitochondria (SSM), whereas age did not affect RNA oxidation in (B) interfibrillar mitochondria (IFM). With age, RNA oxidation was significantly increased in (C) liver mitochondria. Data are expressed as mean ± SEM (n = 4–7). a,bDifferent letters indicate values are significantly different (p < 0.05).
