Table 3.
Studies on endothelial function by arterial tonometry or vasodilation in response to pharmacological stimuli in migraineurs
| Study (First author, year) | Study design | Patients included (n) | % women | Exclusion criteria | Migraine diagnosis | Results |
|---|---|---|---|---|---|---|
| Arterial tonometry |
|
|
|
|
|
|
| Jiménez-Caballero, 2013
[31] |
CC |
CM: 21 |
71 |
Age ≥50, CVD, inflammatory disease, obesity, HYP, DM, dyslipidemia, CS, active cancer, ovarium pathology, pregnancy or lactation, regular use of vasoactive drugs |
ICHD-II |
Smaller RHI in migraineurs |
| Controls: 21 | ||||||
| Liman, 2012
[32] |
CC |
MwA: 29 |
100 |
CVD, obesity, HYP, DM, pregnancy, use of drugs (statins, anticoagulants or antiplatelet and intake of triptans within the previous 24 h) |
ICHD-II |
No differences in PAT ratio between migraineurs and controls |
| Controls: 30 | ||||||
| Vasodilation in response to pharmacological stimuli | ||||||
| De Hoon, 2006
[20] |
CC |
Migraine: 10 |
60 |
CVD, HYP, DM, dyslipidemia, CS |
ICHD-I |
No differences between migraineurs and controls in vasodilation response to serotonin, sodium nitroprusside, and CGRP |
| Controls: 10 | ||||||
| Edvinsson, 2008
[33] |
CC |
MwoA: 9 |
78 |
None |
ICHD-I |
No differences between migraineurs and controls in vasodilation response after local heating and iontophoretic administration of acetylcholine, sodium nitroprusside, and CGRP |
| Controls: 9 | ||||||
| Napoli, 2009
[34] |
CC |
MwoA: 12 |
58 |
HYP, DM, hypercholesterolemia, CVD, CS |
ICHD-I |
Reduced response to endothelium-dependent vasodilation and production of cGMP in migraineurs; no difference in production of NO |
| Controls: 12 | ||||||
| Vanmolkot, 2010
[35] |
CC |
Migraine:16 |
75 |
Age >50, CVD, HYP, obesity, DM, CS, dyslipidemia, pregnancy or lactation, use of vasoactive drugs (except OC) |
ICHD-II |
No differences between migraineurs and controls to sodium nitroprusside, substance P, and NG-monomethyl-L-arginine |
| Controls: 16 | ||||||
| Yetkin, 2007
[30] |
CC |
Migraine: 24 |
89 |
HYP, CAD, DM, infectious disease |
ICHD-I |
Higher nitrate-mediated dilation in migraineurs |
| Controls: 26 | ||||||
CC case–control; CM chronic migraine; MwA migraine with aura; MwoA migraine without aura; CVD cardiovascular disease; HYP arterial hypertension; DM,diabtes mellitus; CS cigarette smoking; OC oral contraceptive; ICHD International classification headache disorders; RHI reactive hyperhemia index; PAT peripheral arterial tonometry; CGRP Calcitonin Gene Related Peptide; cGMP cyclic guanosine monophosphate; NO nitric oxide.