Table 4.
Studies on endothelial function by endothelial progenitor cells in migraineurs
| Study (First author, year) | Study design | Patients included (n) | % women | Exclusion criteria | Migraine diagnosis | Results |
|---|---|---|---|---|---|---|
| Lee, 2008
[36] |
CC |
Migraine: 92 |
70 |
CVD, diabetic retinopathy |
ICHD-II |
Decreased number and migratory capacity and higher senescence levels of endothelial progenitor cells in migraineurs versus controls |
| (MwoA: 67; MwA: 25) | ||||||
| Controls: 37 | ||||||
| Oterino, 2013
[37] |
CC |
CM: 51 |
73 |
CVD, inflammatory disease, cancer or treatment with antimitogen agents, pregnancy in the last year |
ICHD-I |
Higher number of activated endothelial progenitor cells in migraineurs |
| EM: 48 | ||||||
| Controls: 35 | ||||||
| Rodriguez-Osorio, 2012
[23] |
CC |
Migraine : 47 |
98 |
CAD, inflammatory disease, obesity, HYP, DM, dyslipidemia, CS, infectious disease, severe systemic disease; ovarium pathology, pregnancy or lactation, use of vasoactive drugs |
ICHD-II |
Lower endothelial progenitor cell counts in migraineurs |
| (MwA:14; MwoA: 33) | ||||||
| Controls: 23 |
CC case–control; CM chronic migraine; EM episodic migraine; MwA migraine with aura; MwoA migraine without aura; CVD cardiovascular disease; CAD coronary artery disease; HYP arterial hypertension; DM diabetes mellitus; CS cigarette smoking; ICHD International classification headache disorders.