Table 4.
Toxicity assessment during cycles 2 to 5 of chemotherapy
| Number of patients (n = 6) |
Number of events (n=74) |
|||||
|---|---|---|---|---|---|---|
| Adverse Event | Total | Grade 1–2 | Grade 3–4 | Total | Grade 1–2 | Grade 3–4 |
| Hematologic | 6 | 6 | 4 | 38 | 27 | 11 |
| Anemia | 4 | 3 | 2 | 5 | 3 | 2 |
| Lymphopenia | 5 | 2 | 4 | 10 | 4 | 6 |
| Neutropenia | 6 | 6 | 2 | 13 | 10 | 3 |
| Thrombocytopenia | 5 | 5 | 0 | 10 | 10 | 0 |
| Nonhematologic | 6 | 6 | 2 | 41 | 38 | 3 |
| Abdominal pain | 3 | 2 | 1 | 3 | 2 | 1 |
| ALP elevated | 1 | 1 | 0 | 1 | 1 | 0 |
| ALT elevated | 3 | 3 | 0 | 3 | 3 | 0 |
| Anorexia | 1 | 1 | 0 | 1 | 1 | 0 |
| Ascites | 1 | 1 | 0 | 1 | 1 | 0 |
| AST elevated | 3 | 3 | 0 | 3 | 3 | 0 |
| Diarrhea | 3 | 3 | 0 | 6 | 6 | 0 |
| Dizziness | 2 | 2 | 0 | 2 | 2 | 0 |
| Fatigue | 1 | 1 | 0 | 1 | 1 | 0 |
| Hematochezia | 1 | 1 | 0 | 1 | 1 | 0 |
| Hypoalbuminemia | 1 | 1 | 0 | 1 | 1 | 0 |
| Hypocalcemia | 1 | 1 | 0 | 1 | 1 | 0 |
| Hypokalemia | 3 | 3 | 0 | 3 | 3 | 0 |
| Mood alteration | 1 | 1 | 0 | 1 | 1 | 0 |
| Nasal bleed | 2 | 2 | 0 | 2 | 2 | 0 |
| Nausea | 1 | 1 | 0 | 1 | 1 | 0 |
| Pruritus | 1 | 1 | 0 | 1 | 1 | 0 |
| Skin fissures | 1 | 1 | 0 | 1 | 1 | 0 |
| Skin rash | 3 | 3 | 1 | 4 | 3 | 1 |
| Vomiting | 1 | 1 | 0 | 1 | 1 | 0 |
| Weight loss | 2 | 1 | 1 | 2 | 1 | 1 |
| Wheezing | 1 | 1 | 0 | 1 | 1 | 0 |