Table 1.
Network of the interactions of the miRNA target genes
| Category | Genes | Upstream miRNAs | Z-score/ p-value |
|---|---|---|---|
| Migration of Phagocytes |
CCL2, CCL7, CD40, CSF1, FN1, MMP14, PLAU, PLXND1, SERPINE1, SOCS3 |
mir-1, mir-133, mir-143-3p, mir-145-5p, mir-23a-3p, mir-28-5p, mir-455-5p |
2.627/1.05E-2 |
| Proliferation of Mononuclear Leukocytes |
ANPEP, CD1D, CD276, CD28, CD40, CD84, CSF1, DPP4, FN1, FTL, ICOS, IL18, IL2RA, KLF4, KLRC4-KLRK1/KLRK, LILRB1, MYC, PIM1, PNP, PTPRJ, THBS1, TIGIT, TNFRSF10B, TNFRSF9, TNFSF13, ULBP2 |
mir-1, mir-133, mir-140-3p, mir-143-3p, mir-145-5p, mir-23a-3p, , mir-28-3p, mir-28-5p, mir29b-3p, mir-455-5p |
2.612/2.66E-6 |
| Cell Movement of Mononuclear Leukocytes |
ADAM17, CCL2, CCL7, CD28, F11R, FN1, ICOS, IL18, ITGAL, MMP14, PDGFB, PLAU, PTPRO, RGS1, SERPINE1, SOCS3, THBS1, TLR4 |
mir-1, mir-133, mir-140-3p, mir-143-3p, mir-145-5p, mir-23a-3p, mir-28-3p, mir-28-5p, mir-29b-3p, mir-455-5p |
2.316/2.66E-3 |
| Cell Movement of Smooth Muscle cells |
CCL2, CSF1, FN1, IL18, PLAU, PTGS2, THBS1, TRIB1 |
mir-1, mir-143-3p, mir-23a-3p, mir-28-5p |
2.201/1.20E-3 |
| Differentiation of Macrophages |
CDC42, CSF1, LIF, MYB, PRDM1, TLR4 |
mir-133, mir-140-3p, mir-145-5p, mir-23a-3p, mir-28-5p, mir-29b-3p |
2.166/5.70E-3 |
| Stimulation of T Lymphocytes |
CD28, CD40, DPP4, FN1, ICOS, IL18, KLRC4-KLRK1/KLRK1 |
mir-1, mir-133, mir-143-3p, mir-145-5p, mir-28-3p, mir-28-5p, mir-29-3p, |
2.000/7.39E-5 |
| Cell Death of Vascular Endothelial Cells |
BCL2L1, IL18, LRP1, MAPK1, PMAIP1, THBS1, TNFRSF10B, TNFSF15 |
mir-1, mir-133, mir-143-3p, mir-143-5p, mir-23a-3p, mir-28-5p, |
1.811/4.47E-3 |
| Migration of Endothelial Cells |
CCL2, COL4A1, DPP4, FN1, HOXA9, MMP14, NRP1, PDGFB, PIM1, PTGS2, SCARB1, SCG2, SERPINE1,TGFBR1,THBS1,TNFSF15 |
mir-1, mir-133, mir-143-3p, mir-145-5p, mir-23a-3p, mir-29b-3p |
1.610/2.19E-3 |
| Cell Movement of Endothelial Cells |
ANPEP, CCL2, CDH2, COL4A1, DPP4, FN1, HOXA9, MMP14, NRP1, PDGFB, PIM1, PTGS2, SCARB1, SCG2, SERPINE1, TGFBR1, THBS1, TNFSF15 |
mir-1, mir-133, mir-143-3p, mir-145-5p, mir-23a-3p, mir-29b-3p |
1.606/8.83E-4 |
| Apoptosis of Vascular Endothelial Cells |
BCL2L1, IL18, LRP1, MAPK1, PMAIP1, THBS1, TNFRSF10B |
mir-1, mir-133, mir-140-3p, mir-143-3p, mir-145-5p, mir-23a-3p, mir-28-5p |
1.525/1.02E-2 |
| Proliferation of Smooth Muscle Cells |
CCL2, FOS, MAPK1, PDGFB, SERPINE1, ST8SIA1, THBS1, TLR4, TNFAIP3, TRIB1 |
mir-1, mir-143-3p, mir-140-3p, mir-145-5p, mir-23a-3p, mir-28-5p, mir-29b-3p, mir-455-5p |
1.037/1.83E-3 |
| Proliferation of Endothelial Cells | CDH2, COL4A1, COL4A3, CSF1, DAB2, F11R, FN1, LPAR2, NRP1, PDGFB, PIM1, SCG2, TGFBR1, THBS1, TNFSF15 | mir-1, mir-133, mir-140-3p, mir-143-3p, mir-145-5p, mir-23a-3p, mir-28-5p, mir-29b-3p | -1.600/3.16E-3 |
The P value indicates the likelihood of the focus genes in a network being found together as a result of random chance. Using a 99% confidence level, z-scores of 2 were considered significant. Significances for the enrichment of the genes in a network with particular biologic functions or canonical pathways were determined via right-tailed Fisher’s exact test and the whole database as a reference set. The same computation was used for gene ontology analyses of the initial gene list. The columns are arranged in descending order of z-score.