Table 2.
Echocardiographic characteristics of the study population, stratified by standard echo criteria for HCM1,3
| Normal screening echo (n = 64) | Borderline HCM (n = 24) | Definite HCM (n = 19) | Test statistic* | P-value | |
|---|---|---|---|---|---|
|
2D-TM Data: mean [SD] | |||||
|
IVSd (mm) |
10.30 (2.17) |
12.38 (2.36) |
15.53 (4.50) |
F= 27.33 |
<0.0001 |
|
LVPWd (mm) |
9.22 (1.67) |
11.00 (2.57) |
11.32 (2.31) |
F=11.79 |
<0.0001 |
|
IVS/LVPW ratio |
1.13 (0.20) |
1.17 (0.33) |
1.38 (0.33) |
F=6.77 |
0.0017 |
|
LVIDd (mm) |
48.86 (5.76) |
50.42 (6.00) |
47.16 (7.92) |
F= 1.45 |
0.239 |
|
LA diameter (mm) |
34.75 (5.62) |
38.98 (4.02) |
36.72 (4.96) |
F= 5.73 |
0.0044 |
|
LVEF M Mode (%) |
61.81 (7.08) |
66.17 (7.46) |
68.33 (11.82) |
F=5.67 |
0.0046 |
|
LVOT gradient (mmHg) |
5.32 (1.87) |
5.91 (2.39) |
7.00 (3.27) |
F=3.35 |
0.0399 |
|
RWT (mm) |
0.38 (0.06) |
0.44 (0.07) |
0.50 (0.08) |
F=26.78 |
<0.0001 |
|
MWT (mm) |
10.62 (1.13) |
13.42 (0.50) |
17.63 (3.65) |
F= 118.46 |
<0.0001 |
|
Maximal LV wall dimensions in diastole: |
|
|
|
|
|
|
Antero- septal wall (mm) |
10.12 (1.37) |
12.58 (1.10) |
16.63 (3.39) |
F=93.87 |
<0.0001 |
|
Postero- septal wall (mm) |
9.88 (1.32) |
12.67 (1.27) |
15.84 (4.57) |
F=55.64 |
<0.0001 |
|
Antero-lateral wall (mm) |
9.22 (1.13) |
10.83 (1.61) |
11.53 (2.09) |
F=23.74 |
<0.0001 |
|
Posterior wall (mm) |
9.25 (1.09) |
10.96 (1.08) |
11.68 (2.03) |
F=32.74 |
<0.0001 |
|
LV Mass (g) |
172.55 (48.34) |
230.29 (60.66) |
268.53 (133.37) |
F=14.96 |
<0.0001 |
|
Pulsed Doppler | |||||
|
Peak E velocity (cm/s) |
0.80 (0.17) |
0.73 (0.22) |
0.79 (0.14) |
F=1.60 |
0.206 |
|
Peak A velocity (cm/s) |
0.58 (0.17) |
0.58 (0.13) |
0.60 (0.18) |
F=0.16 |
0.854 |
|
E/A ratio |
1.49 (0.49) |
1.31 (0.51) |
1.45 (0.61) |
F=0.98 |
0.379 |
|
E deceleration time (ms) |
187.87 (60.29) |
203.50 (33.91) |
220.11 (61.30) |
F=2.60 |
0.079 |
|
Tissue Doppler | |||||
|
Septal Sa (cm/s) |
8.25 (2.35) |
7.68 (2.48) |
7.10 (1.99) |
F=1.54 |
0.220 |
|
Septal Ea (cm/s) |
10.22 (3.33) |
7.01 (3.29) |
7.90 (3.90) |
F=8.02 |
0.0006 |
|
Septal Aa (cm/s) |
8.89 (2.11) |
8.96 (3.58) |
8.09 (2.64) |
F=0.60 |
0.550 |
|
Lateral Sa (cm/s) |
10.13 (3.38) |
8.41 (3.14) |
8.29 (2.44) |
F=3.18 |
0.047 |
|
Lateral Ea (cm/s) |
12.87 (5.99) |
9.95 (4.03) |
11.19 (4.27) |
F=2.52 |
0.087 |
|
Lateral Aa (cm/s) |
8.85 (2.99) |
7.87 (3.39) |
7.78 (3.50) |
F=1.06 |
0.350 |
|
Echocardiograph composite scores | |||||
|
Adjusted 2D-LVH score |
36.28 (2.69) |
39.71 (2.69) |
39.03 (2.80) |
F=12.33 |
<0.0001 |
|
Spirito index (mm) |
38.47 (3.71) |
47.04 (3.03) |
55.68 (9.53) |
F=90.81 |
<0.0001 |
| Gandjbakhch risk score | −2.78 (1.59) | −0.95(3.77) | 0.57 (2.59) | F=11.91 | <0.0001 |
* Comparisons across the strata of echo findings were made using ANOVA.
IVSd Interventricular septum diameter in diastole.
LVPWd Left ventricular posterior wall diameter in diastole.
LVIDd Left ventricular internal diameter in diastole.
LA Left atrium.
LVEF Left ventricular ejection fraction.
LVOT Left ventricular outflow tract.
RWT Relative wall thickness.
MWT Maximal wall thickness.