Table 5.
HCM screening and the effect of the addition of the troponin measures screening models, using logistic regression with boderline or definite HCM findings at echo as the dependent variable
| Model | Covariables | n | Pseudo R2 | AUROC (95% CI) |
|---|---|---|---|---|
|
Simple model |
Age, sex and symptoms |
104 |
0.177 |
0.75 (0.65, 0.86) |
|
Screening model |
Age, sex, symptoms and “Group 2” ECG changes |
104 |
0.189 |
0.77 (0.67, 0.87) |
|
Enhanced screening model with cTnI |
Age, sex, symptoms, “Group 2” ECG changes and ln(cTnI) |
104 |
0.201 |
0.75 (0.63, 0.86) |
| Enhanced screening model with hsTnI | Age, sex, symptoms, “Group 2” ECG changes and ln(hsTnI) | 104 | 0.225 | 0.78 (0.69, 0.88) |
Footnote: Integrated discrimination index (IDI) for the addition of the ln(cTnI) to the “Screening” model is 0.025 (standard error 0.024), p=0.299. Integrated discrimination index (IDI) for the addition of the ln(hsTnI) to the “Screening” model is 0.036 (standard error 0.019), p=0.056.