Table 3. Multi-adjusted logistic regression analysis for the association between ACE polymorphisms and prevalent depressiona according to history of major depression.

SNP and genotype	P-interaction	Without history of major depression (n=757)		With history of major depression (n=248)
		OR (95% CI)b	P	OR (95% CI)b	P
rs1800764
TT	0.08	—	—	—	—
CT		0.69 (0.45–1.05)	0.08	1.21 (0.65–2.24)	0.54
CC		0.41 (0.24–0.70)	0.001	1.17 (0.52–2.64)	0.70
rs4291
AA	0.14
AT		0.67 (0.44–1.00)	0.05	0.97 (0.54–1.72)	0.91
TT		0.36 (0.20–0.65)	0.0007	1.08 (0.42–2.78)	0.88
rs4295
CC	0.06	—	—	—	—
CG		0.61 (0.41–0.91)	0.01	1.07 (0.60–1.93)	0.82
GG		0.34 (0.19–0.62)	0.0004	1.16 (0.46–2.93)	0.75
rs4311
CC	0.05	—	—	—	—
CT		0.61 (0.39–0.95)	0.03	1.68 (0.84–3.38)	0.15
TT		0.39 (0.23–0.66)	0.0004	0.94 (0.40–2.24)	0.89
rs4333
CC	0.17	—	—	—	—
CT		0.70 (0.43–1.14)	0.15	1.30 (0.64–2.61)	0.47
TT		0.46 (0.27–0.79)	0.005	1.02 (0.45–2.31)	0.97
rs4343
AA	0.01	—	—	—	—
AG		0.56 (0.35–0.90)	0.02	2.02 (0.94–4.36)	0.07
GG		0.40 (0.23–0.67)	0.0005	1.51 (0.64–3.56)	0.35
rs4351
AA	0.08	—	—	—	—
AG		0.61 (0.38–0.98)	0.04	1.49 (0.72–3.10)	0.28
GG		0.42 (0.25–0.71)	0.001	1.18 (0.51–2.71)	0.70

Abbreviations: ACE, angiotensin-converting enzyme; CES-D, Center for Epidemiologic Studies-Depression Scale; CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism.

^aCorresponds to current major depression or a CES-D score⩾16.

^bModel adjusted for age, gender, education, cardiovascular ischemic pathologies, cognitive impairment, ApoE2, high blood pressure, antihypertensive and antidepressant drugs.