Table 1. DE and MPD of prednisolone-carrier binary systems (standard deviations were all less than 10%).
| Sample |
Pure drug |
Solid dispersion |
Treated Physical mixture |
Physical mixture | |||||
| Drug Carrier Ratio | - | 1:10 | 1:20 | 1:40 | 1:40 | 1:10 | 1:20 | 1:40 | |
|
Without carrier |
DE | 20.65 | - | - | - | - | - | - | - |
| MPD | 18.32 | - | - | - | - | - | - | - | |
| Lactose | DE | - | 80.98 | 83.18 | 80.71 | 71.24 | 65.39 | 73.73 | 70.24 |
| MPD | - | 73.05 | 75.12 | 72.95 | 63.77 | 57.80 | 66.60 | 62.45 | |
| Dextrin | DE | - | 50.62 | 62.49 | 68.82 | 65.28 | 31.42 | 38.11 | 39.51 |
| MPD | - | 45.10 | 56.00 | 61.31 | 58.37 | 27.47 | 33.68 | 34.41 | |
| PEG 6000 | DE | - | 60.93 | 60.78 | 53.74 | 55.18 | 42.36 | 51.61 | 43.25 |
| MPD | - | 53.95 | 52.90 | 46.05 | 48.42 | 35.76 | 44.14 | 37.17 | |