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The cytogenetics diagnostic algorithm. MYC rearrangement is recommended on lymphoma cases with increased Ki67 expression (> 90%). Molecular Burkitt Lymphoma (BL) is defined only by the presence of the MYC-IG rearrangement, an early and frequent event; Diffuse Large B-cell Lymphoma (DLBCL) is cytogenetically set by the absence of MYC aberration; Intermediate BL/DLBCL are defined by unstable phenotype, generally MYC rearrangement is a second event and it doesn’t involve IG locus.
