Figure 7.

Model of neuronal Aβ clearance by LRP1. APP is cleaved and processed to Aβ in the endosomes upon endocytosis, and Aβ is secreted from the neuron into the brain ISF. LRP1 is abundantly expressed in neurons, predominantly in the postsynaptic region and cell body. As an efficient endocytic receptor, LRP1 mediates Aβ uptake and subsequent lysosomal degradation. Although Aβ is also eliminated through proteolytic enzymes, glial cell, and cerebrovascular system, disturbance of the LRP1 pathway is sufficient to induce Aβ accumulation and deposition in the cortex as shown in this work.