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Primary structure of sirtuins. The seven mammalian sirtuins (SIRT1–7) are aligned with yeast Sir2p (yeast has four other SIR2 paralogs, HST1–4). The conserved, catalytic domain that all sirtuins have in common is in yellow. Nuclear localization sequences (NLSs) and mitochondrial targeting sequences (MTSs) are also indicated. Numbers refer to amino acid residues in the proteins.
