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. 2013 Oct 1;27(19):2086–2098. doi: 10.1101/gad.224899.113

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© 2013 Ruffell et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 2. — Stromal and epithelial cells express CtsC. Localization of CtsC (green) within dysplastic skin of HPV16/CtsC^+/− mice (6 mo of age) (A) and mammary tumors from MMTV-PyMT mice (B). CtsC was highly expressed in F4/80⁺ macrophages, CD45⁻PDGFRα⁺ fibroblasts, and epithelial cells in both transgenic models. While CtsC was also expressed by CD31⁺ endothelial cells and SMA⁺ pericytes in mammary tumors, CtsC localization was prominent in CD117⁺ mast cells in HPV16/CtsC^+/− ear tissue. (C) Immunofluorescent confocal microscopy of human skin SCCs and breast tumors revealing CtsC expression (green) in the stromal compartment, which colocalized to infiltrating CD45⁺ immune cells and CD68⁺ macrophages (red), in addition to localization to the epithelial compartment of tumors. (Dashed line) Epithelial–dermal interface; (e) epidermis.