Topology and phylogeny of the REIL proteins from A. thaliana. A, Topology of A. thaliana REIL genes and proteins. The REIL1 and REIL2 genes have five conserved exons. The respective REIL proteins, namely the 404-amino acid REIL1 and the 395-amino acid REIL2 protein, contain four zinc finger domains and two additional conserved domains, CD1 and CD2. The mutants, reil1-1 (SALK_090486), reil2-1 (GK_166C10), and reil2-2 (SALK_040068), carry T-DNA insertions in exon 2 (compare with arrow heads). B, Phylogenetic analysis of the plant REIL proteins. The plant REIL proteins were subject to gene duplications, which occurred independently in several plant phylae. The REIL1 and the REIL2 paralogs of A. thaliana originated from gene duplication during the speciation of the Brassicales.