Fig. (3).

Graph displaying cumulative food intake in the first 24h after each immunization in normal weight (A) and DIO mice (B). Vaccinated normal weight mice, after the first two inoculations, depicted an acute decrease in food intake when compared to the PBS controls, corresponding to 95.3% and 94.8% of the PBS control, respectively (A). Vaccinated DIO mice also displayed a significant decrease of food intake in the first 24 hours after each inoculation of the immunoconjugate, corresponding to 66.16% (p=0.036), 82.22% (p=0.008) and 50.09 % (p=0.039) of the food intake of the PBS control group, respectively (B).