Table 4.
Odds ratios for risk of meningioma associated with estimated occupational exposure to chlorinated solvents (National Cancer Institute Brain Tumor Case-control Study, 1994–1998)
| Chlorinated Solvent | Exposure status | Controls n (%) | Cases n (%) | ORa (95% CI) | ORb (95% CI) |
|---|---|---|---|---|---|
| Any solvent | Unexposed | 466 (84.0) | 131 (89.1) | 1.0 | |
| Exposed | 89 (16.0) | 16 (10.9) | 0.8 (0.4, 1.4) | ||
| Methylene chloride (DCM) | Unexposed | 534 (67.0) | 147 (74.6) | 1.0 | 1.0 |
| Possible | 210 (26.4) | 42 (21.3) | 0.9 (0.6, 1.3) | 1.6 (0.7, 3.5) | |
| Probable | 53 (6.6) | 8 (4.1) | 0.8 (0.4, 1.8) | 0.8 (0.2, 3.0) | |
| Chloroform | Unexposed | 551 (69.1) | 150 (76.1) | 1.0 | 1.0 |
| Possible | 225 (28.2) | 39 (19.8) | 0.7 (0.5, 1.1) | 0.9 (0.4, 1.9) | |
| Probable | 21 (2.6) | 8 (4.1) | 1.3 (0.5, 3.1) | 1.9 (0.6, 5.9) | |
| Carbon tetrachloride | Unexposed | 576 (72.3) | 158 (80.2) | 1.0 | 1.0 |
| Possible | 192 (24.1) | 32 (16.2) | 0.6 (0.4, 1.0) | 0.5 (0.2, 1.1) | |
| Probable | 29 (3.6) | 7 (3.6) | 1.2 (0.5, 3.0) | 0.6 (0.1, 2.9) | |
| 1,1,1-Trichloroethane (TCA) | Unexposed | 525 (65.9) | 146 (74.1) | 1.0 | 1.0 |
| Possible | 260 (32.6) | 46 (23.4) | 0.8 (0.5, 1.2) | 0.9 (0.4, 2.1) | |
| Probable | 12 (1.5) | 5 (2.5) | 2.3 (0.7, 7.2) | 4.1 (0.6, 28.6) | |
| Trichloroethylene (TCE) | Unexposed | 528 (66.3) | 145 (73.6) | 1.0 | 1.0 |
| Possible | 242 (30.4) | 46 (23.4) | 0.8 (0.5, 1.2) | 1.0 (0.4, 2.2) | |
| Probable | 27 (3.4) | 6 (3.0) | 1.2 (0.5, 3.2) | 1.5 (0.4, 6.3) | |
| Perchloroethylene (PERC) | Unexposed | 522 (65.5) | 142 (72.1) | 1.0 | 1.0 |
| Possible | 255 (32.0) | 52 (26.4) | 0.9 (0.6, 1.3) | 1.0 (0.5, 2.2) | |
| Probable | 20 (2.5) | 3 (1.5) | 0.5 (0.1, 1.7) | 0.3 (0.1, 1.7) |
a
Odds ratios computed using unconditional logistic regression adjusting for age group (<30, 30–49, 50–69, 70+), race (white vs. non-white), sex, hospital and proximity of residence to the hospital.
b
Odds ratios computed as above, and additionally adjusting for all other solvents.