Table 2.

Summary of the literature cases regarding pathological features of MP pneumonia in human and animal models.

Category	No. of reports/cases	Alveolar		PBVA		Reference
		Number of cases positive for infiltration with
		Neu	Lym	Lym	Plasma
Autopsy	7/16	9	3	9	11	[6–12]
Open lung biopsy and video-assisted thoracic surgery	6/13	3	0	11	9	[13–17,18]
Transbronchial lung biopsy	6/7	0	1	4	2	[19–21]
Murine model	11/11	6	3	10	0	[26,31,33,36–43]
Day 1–3 (n)		5	3	6
Day 4–7 (n)		1	1	3
Day 8– (n)		1	1	3
Hamster model	4					[44–47]
Guinia-pig model	1					[48]
Day 1–3 (n)				1
Day 4–7 (n)				2
Day 8– (n)				4

Neu: neutrophil, Lym: lymphocyte, Plasma: plasma cell, Alveolar: alveolar area, PBVA: peri-bronchovascular area.

(n): number of positive cases at various phases (early: day 1–3, middle: day 4–7, late stage: day 8–, in each report. If the one mouse model had lymphocytes infiltration in the alveolar area from an early to middle stage, this was counted as early (n=1) and middle stage (n=1).