Table 2.
Cytoadherence of Plasmodium vivax and Plasmodium falciparum isolates in HMVEC-L basal and stimulated with TNF-α
| |
|
|
Adherence (% of inhibition) |
|---|---|---|---|
|
Isolate |
Adherence1 |
Anti-CD54 |
|
|
P. vivax |
Basal |
Stimulated TNF-α |
|
| (code) | |||
|
0.012 |
19.0 ± 1 |
27.0 ± 2 |
ND |
|
0.013 |
19.5 ± 2.5 |
39.5 ± 5.5 |
ND |
|
0.014 |
10.5 ± 1.5 |
33.5 ± 3.5 |
ND |
|
0.015 |
4.0 ± 1 |
24.5 ± 2.5 |
ND |
|
0.017 |
42.0 ± 4 |
51.0 ± 16 |
ND |
|
0.018 |
28.0 ± 3 |
52.0 ± 7 |
31.5 (39.4) |
|
0.019 |
38.0 ± 9 |
58.5 ± 6.5 |
34 (41.9) |
|
0.022 |
37.0 ± 11 |
81.5 ± 2.5 |
36.5 (55.2) |
|
0.024 |
53.0 ± 6 |
77.5 ± 10.5 |
33.5 (56.8) |
|
0.025 |
28.5 ± 6.5 |
67.5 ± 3.5 |
23.5 (56.8) |
|
0.026 |
55.5 ± 7.5 |
69.5 ± 11.5 |
27 (61.2) |
|
0.027 |
35.5 ± 10.5 |
47.0 ± 8 |
42 (10.6) |
|
0.028 |
22.0 ± 4 |
48.5 ± 4.5 |
22 (54.6) |
|
P. falciparum |
|
|
|
|
0.033 |
58.5 ± 13.4 |
113 ± 16.9 |
|
|
0.034 |
17 ± 7.1 |
53 ± 8.5 |
|
|
0.035 |
475 ± 38.2 |
1050 ± 74.9 |
|
|
0.036 |
97 ± 8.5 |
259 ± 24 |
|
| FCR3 | 201 ± 49.8 | 465 ± 61 | |
P. vivax and P. falciparum isolates cytoadherence to microvascular line of human lung endothelium HMVEC-L, from the isolate code 0.018 – 0.028 the percentage of adherence inhibition is described, compared to endothelial cells treated with TNF.
1. Average ± standard deviation of Pv-iEs per 200 HMVEC-L.