Figure 2.

IOP (mean ± SD) in intravitreally tPA-treated and contralateral control eyes of sheep (N = 2). All eyes were also treated with prednisolone acetate starting 7 days prior to tPA administration and continuing for the duration of the experiment. Tissue plasminogen activator–treated eyes received 100 μg of tPA each, while contralateral eyes received the equivalent amount of arginine (4.23 mg). IOP decreased within 24 hours in tPA-treated eyes and remained lower than that of the contralateral eyes for at least 7 days. *P < 0.003, ANOVA, post hoc testing.