Table 2.
Association of 12 SNPs with rickets in cases and controls
|
Gene |
SNP |
MAF |
pfor HWET |
A/a |
Allele-specific (unadjusted) |
Allele-specific (adjusted) |
||
|---|---|---|---|---|---|---|---|---|
| pvalue | OR (95% CI) | pvalueb | OR (95% CI) | |||||
| GC |
rs4588 |
0.31 |
0.30 |
Ca/A |
0.003△ |
0.587 (0.412-0.836) |
0.003△ |
0.583 (0.409-0.833) |
| rs7041 |
0.26 |
0.29 |
T/Ga |
0.252 |
1.216 (0.867-1.705) |
0.167 |
1.272 (0.901-1.791) |
|
| rs222020 |
0.34 |
0.67 |
T/Ca |
0.009△ |
1.526 (1.117-2.085) |
0.009△ |
1.517 (1.108-2.078) |
|
| rs2282679 |
0.32 |
0.22 |
Aa/C |
0.010△ |
0.636 (0.449-0.900) |
0.010△ |
0.631 (0.444-0.895) |
|
| rs2298849 |
0.32 |
0.98 |
T/Ca |
0.001△ |
1.709 (1.250-2.338) |
0.001△ |
1.722 (1.256-2.362) |
|
| CYP2R1 |
rs10741657 |
0.43 |
0.25 |
Ga/A |
0.019△ |
1.467 (1.070-2.011) |
0.016△ |
1.477 (1.075-2.030) |
| rs10766197 |
0.45 |
0.36 |
Ga/A |
0.374 |
0.855 (0.619-1.179) |
0.416 |
0.874 (0.632-1.209) |
|
| rs12794714 |
0.43 |
0.36 |
G/Aa |
0.089 |
1.322 (0.968-1.804) |
0.075 |
1.330 (0.971-1.820) |
|
| rs1562902 |
0.47 |
0.46 |
Ta/C |
0.120 |
1.279 (0.940-1.740) |
0.115 |
1.284 (0.941-1.751) |
|
| rs2060793 |
0.27 |
0.42 |
Ga/A |
0.023△ |
0.689 (0.502-0.944) |
0.019△ |
0.684 (0.498-0.940) |
|
| DHCR7/NADSYN1 |
rs3829251 |
0.28 |
0.59 |
G/Aa |
0.297 |
1.204 (0.863-1.680) |
0.342 |
1.176 (0.841-1.645) |
| rs12785878 | 0.49 | 0.13 | Ta/G | 1.000 | 0.993 (0.733-1.345) | 0.879 | 0.977 (0.719-1.326) | |
A/a major allele/minor allele.
arisk allele.
badjusted for sex and BMI.
MAF, minor allele frequency in the study population.
HWE, P values for Hardy–Weinberg Equilibrium test in the study population.
△Significant P values are indicated by a triangle (△P<0.05).