Table 1.
Body weight and body composition, physical activity and meal patterns of wild type (WT), Sox2-Cre:Errβ+/lox, and Sox2-Cre:Errβlox/loxmice
| Genotype | Age |
Body composition |
|
Meal patterns |
||||
|---|---|---|---|---|---|---|---|---|
|
Body weight |
Fat mass |
Lean mass |
Activity |
Pellets |
Satiety ratio |
IMI |
||
| (grams) | (grams) | (grams) | (beam breaks) | (number) | (IMI/meal size) | (minutes) | ||
| WT |
3 weeks |
13.1 ± 0.5 |
2.09 ± 0.09 |
10.06 ± 0.41 |
|
|
|
|
|
Sox2-Cre:Errβ+/lox |
3 weeks |
14.0 ± 0.7 |
2.58 ± 0.16* |
10.56 ± 0.62* |
|
|
|
|
|
Sox2-Cre:Errβlox/lox |
3 weeks |
12.9 ± 0.8 |
1.64 ± 0.17 |
10.51 ± 0.61 |
|
|
|
|
| WT |
9 months |
36.5 ± 0.9 |
12.19 ± 0.65 |
23.09 ± 0.46 |
67207 ± 8601 |
128 ± 15 |
8.3 ± 0.9 |
107 ± 17 |
|
Sox2-Cre:Errβ+/lox |
9 months |
46.1 ± 3.0* |
21.43 ± 1.84* |
24.00 ± 0.63 |
93599 ± 9879 |
238 ± 35* 5.6 ± 0.7# |
102 ± 10 |
|
| Sox2-Cre:Errβlox/lox | 9 months | 28.4 ± 1.3* | 5.69 ± 0.74* | 21.64 ± 0.40* | 133741 ± 20533* | 260 ± 57* | 4.1 ± 0.7* | 67 ± 11* |
*P < 0.05 relative to WT.
#P = 0.05 relative to WT.
Activity is a measurement for the number of beam break, which represents horizontal physical activity that is parallel to the ground.
Meal patterns for Sox2-Cre:Errβlox/lox mice are adapted from [14].