Table 2.
Summary of phenotype difference between Sox2-Cre:Errβ+/lox, Sox2-Cre:Errβlox/loxand Nes2-Cre:Errβlox/loxmice, relative to wild type (WT)
| Phenotype | Sox2 - Cre : Errβ +/lox | Sox2 - Cre : Errβ lox/lox | Nes2 - Cre : Errβ lox/lox | |
|---|---|---|---|---|
| Body Composition | ||||
| Body weight |
↑, |
↓, |
↑ |
|
| Fat mass |
↑, |
↓, |
NC |
|
| Lean mass |
↓, |
↓, |
↑ |
|
| Hormone and Neuropeptides | ||||
| Corticosterone |
↑, |
↓, |
NA |
|
| Corticosterone (DY131) |
↑, |
↓, |
NA |
|
|
Crh expression |
↑, |
↑, |
↓ |
|
|
Crh expression (DY131) |
↑↑, |
↑↑, |
NA |
|
|
Npy expression |
↑, |
↑, |
↓ |
|
|
Agrp expression |
↑, |
↑, |
NA |
|
| Stress Behavior | ||||
| Acoustic startle response |
NA, |
NA, |
↑ |
|
| Meal patterns | ||||
| Total pellets consumed |
↑, |
↑, |
NC |
|
| Inter Meal interval (IMI) |
NC, |
↓, |
↓ |
|
| Satiety Ratio | ↓#, | ↓, | ↓ | |
↑ – increase, ↓ – decrease, NC – no change, ↑↑ – increase relative to levels with no DY131 treatment, NA – not available, #P = 0.05 relative to WT; Nes2-Cre:Errβlox/lox data adapted from [14].