Change in medication use over the course of the intervention by diet group. Acute medications included vasoactive abortive medications, acute opioids, and nonsteroidal antiinflammatory drugs; Adjunctive medications included antiemetics, anxiolytics, sleep aids/hypnotics, and muscle relaxants. All changes depicted in Fig. 4 were significantly changed compared to baseline. There was no significant change in the use of Preventive medications (eg, anticonvulsants, antidepressants, vasoactive preventives, long-acting opiates) over time in either group.