Skip to main content
. Author manuscript; available in PMC: 2014 May 10.
Published in final edited form as: Circ Res. 2013 Mar 26;112(10):10.1161/CIRCRESAHA.113.301055. doi: 10.1161/CIRCRESAHA.113.301055

Fig. 5. Regional accumulation of Cx43-P0 observed in I79N after Iso injection in vivo and after treatment of isolated control hearts with the Ca2+ sensitizer EMD57033 (EMD, 3 μM).

Fig. 5

(A) Anti-Cx43 (green) and anti-Cx43-P0 (red) staining of TnT-WT and TnT-79N ventricular tissue after Iso challenge. (B) Summary data for integrated density (mean intensity x area (pixel)) of Cx43 and (C) ratio of Cx43-P0/Cx43. (D) Examples of immunostained tissue from isolated NTG hearts treated with VEH or EMD after rapid pacing. (E+F) Summary data for EMD experiments (for pacing protocol see Supplemental Fig. IA). The scale bar length is100 μm in all images. * p≤0.05 vs WT