Table 1.
Oral vancomycin desensitisation protocol
| Fraction of dose | Dose given (mg) | Cumulative dose (mg) | Volume given (ml) |
|---|---|---|---|
|
Using Solution A, 0.01 mg/ml | |||
| 1/10,000 |
0.025 |
0.025 |
2.5 |
| 1/5,000 |
0.05 |
0.075 |
5 |
| 1/2,500 |
0.1 |
0.175 |
10 |
| 1/1,250 |
0.2 |
0.375 |
20 |
|
Using Solution B, 1 mg/ml | |||
| 1/625 |
0.4 |
0.775 |
0.4 |
| 1/312 |
0.8 |
1.575 |
0.8 |
| 1/160 |
1.5 |
3.075 |
1.5 |
| 1/80 |
3.0 |
6.075 |
3 |
| 1/40 |
6.0 |
12.075 |
6 |
|
Using Solution C, 5 mg/ml | |||
| 1/20 |
12.5 |
24.575 |
2.5 |
| 1/10 |
25 |
49.575 |
5 |
| 1/5 |
50 |
99.575 |
10 |
| 1/ 2.5 |
100 |
199.575 |
20 |
| |
150 |
349.575 |
30 |
| 1/ 1.25 | 200 | 549.575 | 40 |
Make up 1 mg/ml solution (500 mg vancomycin in 500 mls saline or other diluent). This is Solution B.
Make up 0.01 mg/ml solution (Take 1 ml of solution B, dilute it in 100 mls saline.) This is Solution A.
Make up 5 mg/ml solution (500 mg Vancomycin in 100 mls saline or other diluent). This is Solution C.