Table 3.
Genes of interest potentially related to B6 and 129S1 phenotypic differences in CD8 T cell-initiated BBB disruption
Chromosome 12 (Rotarod) | Proposed function | # SNPs different between strains | SNP locations |
---|---|---|---|
Vsnl1 |
Neuronal Ca2+ sensor proteins |
24 |
All I |
Ddx1 |
Viral responses |
2 |
All I |
Trib2 |
Induces apoptosis of cells in hematopoietic origin; CD8 T cells |
40 |
1 Cs, 1 U5, 38 I |
Lpin1 |
Demyelination; actin cytoskeleton reorganization |
531 |
3 Cn, 8 Cs, 27 U3, 493 I |
Kcnf1 |
Neurotransmitter release; neuronal excitability |
35 |
4 Cs, 7 U5, 24 U3 |
Rock2 |
Actin cytoskeleton organization; regulation of angiogenesis |
330 |
1 Cn, 3 Cs, 5 U3, 321 I |
Chromosome 17 (CNS vascular permeability) |
Proposed function |
# SNPs different between strains |
SNP locations |
Pde10a |
Signal transduction; neuronal cell bodies |
1268 |
Unspecified |
Qk |
Myelinization; axon ensheathment; vasculogenesis |
214 |
12 U3, 202 I |
Pacrg |
Myelinization |
265 |
2 U5, 263 I |
Park2 |
Neuron projection; neuron death |
3198 |
2 Cs, 1 U3, 3195 I |
Plg |
Apoptotic processes; vessel development |
38 |
1 Cn, 37 I |
Igf2r |
Edema |
7 |
All I |
Mas1 |
Inflammatory responses |
2 |
All I |
Mllt4 | Adherens junctions; cell junctions | 7 | All I |
Shown are the genes of interest found on chromosome 12 and chromosome 17 along with their proposed functions. The Mouse Phenome Database (http://www.phenome.jax.org) was used to determine the number of SNPs that are different between the B6 and 129S1 mouse strains as well as their location.
(Abbreviations:Cn nonsynonomous codon, Cs synonomous codon, U5 51 UTR variant, U3 31 UTR variant, I intron-variant).