Table 3.

Genes of interest potentially related to B6 and 129S1 phenotypic differences in CD8 T cell-initiated BBB disruption

Chromosome 12 (Rotarod)	Proposed function	# SNPs different between strains	SNP locations
Vsnl1	Neuronal Ca2+ sensor proteins	24	All I
Ddx1	Viral responses	2	All I
Trib2	Induces apoptosis of cells in hematopoietic origin; CD8 T cells	40	1 Cs, 1 U5, 38 I
Lpin1	Demyelination; actin cytoskeleton reorganization	531	3 Cn, 8 Cs, 27 U3, 493 I
Kcnf1	Neurotransmitter release; neuronal excitability	35	4 Cs, 7 U5, 24 U3
Rock2	Actin cytoskeleton organization; regulation of angiogenesis	330	1 Cn, 3 Cs, 5 U3, 321 I
Chromosome 17 (CNS vascular permeability)	Proposed function	# SNPs different between strains	SNP locations
Pde10a	Signal transduction; neuronal cell bodies	1268	Unspecified
Qk	Myelinization; axon ensheathment; vasculogenesis	214	12 U3, 202 I
Pacrg	Myelinization	265	2 U5, 263 I
Park2	Neuron projection; neuron death	3198	2 Cs, 1 U3, 3195 I
Plg	Apoptotic processes; vessel development	38	1 Cn, 37 I
Igf2r	Edema	7	All I
Mas1	Inflammatory responses	2	All I
Mllt4	Adherens junctions; cell junctions	7	All I

Shown are the genes of interest found on chromosome 12 and chromosome 17 along with their proposed functions. The Mouse Phenome Database (http://www.phenome.jax.org) was used to determine the number of SNPs that are different between the B6 and 129S1 mouse strains as well as their location.

(Abbreviations:Cn nonsynonomous codon, Cs synonomous codon, U5 5¹ UTR variant, U3 3¹ UTR variant, I intron-variant).