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. 2013 Oct 3;14:678. doi: 10.1186/1471-2164-14-678

Table 3.

Genes of interest potentially related to B6 and 129S1 phenotypic differences in CD8 T cell-initiated BBB disruption

Chromosome 12 (Rotarod) Proposed function # SNPs different between strains SNP locations
Vsnl1
Neuronal Ca2+ sensor proteins
24
All I
Ddx1
Viral responses
2
All I
Trib2
Induces apoptosis of cells in hematopoietic origin; CD8 T cells
40
1 Cs, 1 U5, 38 I
Lpin1
Demyelination; actin cytoskeleton reorganization
531
3 Cn, 8 Cs, 27 U3, 493 I
Kcnf1
Neurotransmitter release; neuronal excitability
35
4 Cs, 7 U5, 24 U3
Rock2
Actin cytoskeleton organization; regulation of angiogenesis
330
1 Cn, 3 Cs, 5 U3, 321 I
Chromosome 17 (CNS vascular permeability)
Proposed function
# SNPs different between strains
SNP locations
Pde10a
Signal transduction; neuronal cell bodies
1268
Unspecified
Qk
Myelinization; axon ensheathment; vasculogenesis
214
12 U3, 202 I
Pacrg
Myelinization
265
2 U5, 263 I
Park2
Neuron projection; neuron death
3198
2 Cs, 1 U3, 3195 I
Plg
Apoptotic processes; vessel development
38
1 Cn, 37 I
Igf2r
Edema
7
All I
Mas1
Inflammatory responses
2
All I
Mllt4 Adherens junctions; cell junctions 7 All I

Shown are the genes of interest found on chromosome 12 and chromosome 17 along with their proposed functions. The Mouse Phenome Database (http://www.phenome.jax.org) was used to determine the number of SNPs that are different between the B6 and 129S1 mouse strains as well as their location.

(Abbreviations:Cn nonsynonomous codon, Cs synonomous codon, U5 51 UTR variant, U3 31 UTR variant, I intron-variant).