Table 3.
Cardiovascular disease (CVD) risk biomarkers in circulation in Wistar rats fed the different oil supplements
| |
EPA/DHA 1:1 |
EPA/DHA 2:1 |
EPA/DHA 1:2 |
Soybean oil |
Linseed oil |
|||
|---|---|---|---|---|---|---|---|---|
|
Biomarkers |
Mean ± SD |
Mean ± SD |
Mean ± SD |
p |
Mean ± SD |
P |
Mean ± SD |
p |
| CVD RISK MARKERS | ||||||||
|
Inflammation | ||||||||
| CRP (μg/mL) |
147.0 ± 20.5 |
147.1 ± 22.4 |
140.1 ± 52.7 |
|
172.9 ± 38.2 |
|
142.9 ± 52.0 |
|
|
Thrombotic activity | ||||||||
| PAI-1 (μg/mL) |
7.48 ± 1.3 |
8.75 ± 1.8 |
9.18 ± 1.3 |
|
6.45 ± 0.8 |
c0.030 |
7.76 ± 1.1 |
|
|
Endothelial dysfunction | ||||||||
| sVCAM (μg/mL) |
3.41 ± 0.7 |
3.01 ± 0.4 |
4.40 ± 1.3 |
b0.046 |
3.36 ± 1.7 |
|
2.10 ± 0.4 |
a0.001 |
| |
|
|
|
|
|
|
b0.001 |
|
| |
|
|
|
|
|
|
c0.003 |
|
| sICAM (ng/mL) | 0.59 ± 0.2 | 0.61 ± 0.2 | 0.53 ± 0.2 | 0.52 ± 0.1 | 0.59 ± 0.3 | |||
The data are expressed as mean ± SD (standard deviation). a: differences with respect to EPA/DHA 1:1 supplementation; b: differences with respect to EPA/DHA 2:1 supplementation; c: differences with respect to EPA/DHA 1:2 supplementation.