Table 2.

Morphometric features used in SMLSPM and MKSPM, where the curvature values were computed with σ = 2.0, and the nuclear background is defined to be outside the nuclear region, but inside the bounding box of nuclear boundary.

Feature	Description
Nuclear Size	#pixels of a segmented nucleus
Nuclear Voronoi Size	#pixels of the voronoi region, where the segmented nucleus resides
Aspect Ratio	Aspect ratio of the segmented nucleus
Major Axis	Length of Major axis of the segmented nucleus
Minor Axis	Length of Minor axis of the segmented nucleus
Rotation	Angle between major axis and×axis of the segmented nucleus
Bending Energy	Mean squared curvature values along nuclear contour
STD Curvature	Standard deviation of absolute curvature values along nuclear contour
Abs Max Curvature	Maximum absolute curvature values along nuclear contour
Mean Nuclear Intensity	Mean intensity in nuclear region measured in gray scale
STD Nuclear Intensity	Standard deviation of intensity in nuclear region measured in gray scale
Mean Background Intensity	Mean intensity of nuclear background measured in gray scale
STD Background Intensity	Standard deviation of intensity of nuclear background measured in gray scale
Mean Nuclear Gradient	Mean gradient within nuclear region measured in gray scale
STD Nuclear Gradient	Standard deviation of gradient within nuclear region measured in gray scale