Table 2.
Univariate survival analysis for Sirt1 expression and clinico-pathological parameters in PDAC
| Cases | Events | Mean survival (months) | Standard error | Log-rank-test (p-value) | ||
|---|---|---|---|---|---|---|
|
Age at diagnosis |
<=65 years |
56 |
42 |
50.1 |
10.5 |
0.564 |
| |
>65 years |
57 |
47 |
25.1 |
4.4 |
|
|
WHO stage |
I |
11 |
8 |
29.4 |
9.8 |
0.001 |
| |
IIA |
17 |
10 |
52.8 |
11.9 |
|
| |
IIB |
78 |
64 |
33.7 |
7.0 |
|
| |
III |
3 |
3 |
5.6 |
0.8 |
|
| |
IV |
4 |
4 |
11.9 |
4.1 |
|
|
Tumor stage |
T1 |
/ |
/ |
/ |
/ |
|
| |
T2 |
22 |
17 |
29.6 |
6.8 |
0.003 |
| |
T3 |
88 |
69 |
39.6 |
7.3 |
|
| |
T4 |
3 |
3 |
5.6 |
0.8 |
|
|
Nodal status |
N0 |
30 |
20 |
43.3 |
8.8 |
0.060 |
| |
N1 |
83 |
69 |
32.2 |
6.6 |
|
|
State of metastasis |
M0 |
109 |
85 |
42.4 |
6.8 |
0.268 |
| |
M1 |
4 |
4 |
11.9 |
4.1 |
|
|
Grade |
G1 |
7 |
6 |
16.8 |
2.5 |
0.058 |
| |
G2 |
54 |
39 |
37.3 |
6.0 |
|
| |
G3 |
52 |
44 |
29.7 |
7.9 |
|
|
SIRT1-expression |
low |
81 |
58 |
54.1 |
8.9 |
0.002 |
| high | 32 | 31 | 13.0 | 1.7 |