Table 1.

Summary of the clinical features reported for undifferentiated liver embryonal sarcoma in patients aged over 45 years

No.	Reference	Publication year	Sex	Age(years)	Symptoms and signs	Laboratory findings	Location	Size (cm)	Surgery	Adjuvant therapy	Recurrence	Follow-up, duration	Co-morbidity or past history
1	Mattila et al. [4]	1974	F	68	RUQA pain, hepatomegaly	↑ALP, LDH, Bilirubin	R + L	20 × 18 × 15	Rx ext hep	None	Yes	DOD, 5 months	None
2	Tanner et al. [5]	1978	F	66	RUQA pain, vomiting, diarrhea, weight loss, fever, hepatomegaly	↑ALP, GGT	R	NA	HA ligation + pump	5-FU	-	AWD, 8 months	CHD
3	Chang et al. [6]	1983	F	55	RUQA pain, weight loss, diarrhea, hepatomegaly	↑ALP	L	10 × 10 × 8	Left lob	CAV	No	ANED, 12 months	CREST syndrome
4	Ellis et al. [7]	1983	F	86	RUQA pain, RUQA mass	Normal	R	18 × 12 × 12	Tumorectomy	None	Yes	DOD, 2 months	None
5	Forbes et al. [8]	1987	M	69	RUQA pain, nausea, weight loss, general malaise	Normal	NA	NA	None	RT	-	DOD, 10 months	Malaria and resection for colonic carcinoma
6	Forbes et al. [8]	1987	F	49	RUQA pain, nausea, weight loss, general malaise	NA	NA	NA	None	None	-	DOD	None
7	Grazi et al. [9]	1996	F	60	RUQA mass, dyspepsia	Normal	R	22	Rx hep	None	Yes	DOD, 10 months	NA
8	Nishio et al.[3]	2003	F	49	RUQA pain, general fatigue	NA	R	14 × 8 × 8	Rx lob	Adm + Dtic	Yes	DOD, 29 months	None
9	Nishio et al. [3]	2003	M	62	RUQA pain	NA	L	10 × 9 × 7	Left lob	None	No	ANED, 10 months	NA
10	Lepreux et al. [10]	2005	F	51	RUQA pain, dyspnea, edema of the lower limbs	Normal	R	18 × 16	Liver biopsy	CAV	NA	DOD, 2 months (died from septic shock and acute pneumopathy)	NA
11	Lepreux et al. [10]	2005	F	49	RUQA pain, increased abdominal girth	Normal	L	15 × 13	Left lob	MAID, RT	No	ANED, 6 months	NA
12	Agaram et al. [11]	2006	F	50	NA	NA	NA	17	NA	NA	No	ANED, 8 months	NA
13	Scudiere et al. [12]	2006	F	51	NA	↑ALT, AST	R	23 × 16 × 7	Rx lob	NA	NA	NA	Community-acquired pneumonia
14	Ma et al. [13]	2008	F	61	RUQA pain	Normal	R	12 × 9 × 8	Rx hep	None	NA	DOD, 8 months	None
15	Yang et al. [14]	2009	M	46	Upper abdominal pain, fever, mass, hepatomegaly	↑ALT, GGT, AFP HBeAb(+), HBcAb(+)	R	6 × 6 × 5	Rx hep	NA	NA	NA	Hepatitis B cirrhosis and HCC in the left lobe
16	Yang et al. [14]	2009	M	54	Upper abdominal pain, fever, mass, hepatomegaly	↑ALT, AST, GGT	R	13 × 12 × 12	Rx hep	NA	NA	NA	None
17	Kullar et al. [15]	2009	F	52	RUQA pain, RUQA mass	↑ALP	R	18 × 12 × 8	Rx ext hep	Adm + Ifs	Yes	DOD, 12 months	Chemotherapy for ovarian cancer
18	Yoon et al. [16]	2010	F	53	Abdominal discomfort	Normal	R	13 × 12 × 8	Rx hep	None	No	ANED, 6 months	None
19	Massani et al. [17]	2010	F	47	Upper abdominal pain	Normal	R	8	Rx hep	Epi + Ifs; TACE with Epi	Yes	AWD, 29 months	None
20	Li et al. [18]	2010	M	63	RUQA pain, fever	↑ALP	R	20 × 15 × 15	Rx hep	NA	Yes	DOD, 18 months	None
21	Li et al. [18]	2010	M	56	RUQA pain	↑ALP, ALT, AST, GGT	R	13 × 12	Rx hep	TACE with lipiodol, Epi, hydroxycamptothecin	Yes	DOD, 28 months	None
22	Gasljevic et al. [19]	2011	F	58	Asymptomatic	NA	R	11 × 8	Rx lob	Cysplatin + 5-FU + Vcr	No	DOD, 10 months (died from unrelated cause, B-ALL)	None
23	Kim et al. [20]	2011	F	47	Abdominal mass	↑CA-125	L	12 × 10	Left hep	MAID, RT	Yes	AWD, 48 months	None
24	Legou et al. [21]	2012	F	61	Upper abdominal pain, RUQA mass	↑ALP, ALT, AST	L	27 × 22 × 10	Tumorectomy	NA	NA	NA	None
25	Tanaka et al. [22]	2012	F	53	Asymptomatic	Liver function tests were slightly abnormal	R	12 × 11 × 7	Rx lob	None	Yes	DOD, 36 months	Multiple sclerosis
26	Tucker et al. [23]	2012	F	74	Abdominal pain and fullness, back pain	Normal	L	18 × 15 × 13	Left hep	None	No	ANED, 9 months	NA
27	Lightfood et al. [24]	2012	F	78	Abdominal mass	Normal	R	16	Partial right hepatectomy	None	No	ANED, 6 months	NA
28	This report	2013	F	49	Upper abdominal pain	Normal	R	7 × 6 × 5	Rx lob	Traditional Chinese medicine orally	Yes	DOD, 12 months	SLE

5-FU, 5-fluouracil; Adm, doxorubicin; AFP, α-fetoprotein; ALP, alkaline phosphatase; ALT, alanine aminotransferase; ANED, alive with no evidence of disease; AST, aspartate aminotransferase; AWD, alive with disease; B-ALL, B-lymphoblastic leukemia; CA-125, carbohydrate antigen 125; CAV, cyclophosphamide + Adm + Vcr; CHD, coronary heart of disease; CREST syndrome, calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia syndrome; DOD, dead of disease-related cause; Dtic, decarbazine; Epi, epirubicin; F, female; GGT, γ-glutamyl transpeptidase; HA, hepatic artery; HCC, hepatocellular carcinoma; Ifs, ifosfamide; L, left; Left hep, left hepatectomy; Left lob, left lobectomy; M, male; MAID, Adm + Ifs + Dtic + methylprednisolone; NA, not available; R, right; RT, radiation therapy; RUQA, right upper quadrant abdominal; Rx ext hep, extended right hepatectomy; Rx hep, right hepatectomy; Rx lob, right lobectomy; SLE, systemic lupus erythematosus; TACE, transcatheter arterial chemoembolization; Vcr, vincristine.