Table 2. Meta-analysis of the association between TNF-α 238 G/A polymorphism and psoriasis risk.
| Groups | Studies | Subjects (Cases/Controls) | OR [95%CI] | P value | I2 value |
|---|---|---|---|---|---|
| Total studies | |||||
| A vs. G | 14 | 2,104/1,838 | 2.46[2.04-2.96] | <0.001 | 43.0% |
| AG vs. GG | 14 | 2,253/1,947 | 2.69[2.20-3.28] | <0.001 | 31.1% |
| AA vs. GG | 14 | 2,253/1,947 | 1.87[0.79-4.44] | 0.154 | 0.0% |
| AG/AA vs. GG | 14 | 2,253/1,947 | 2.68[2.20-3.26] | <0.001 | 38.4% |
| AA vs. AG/GG | 14 | 2,253/1,947 | 1.64[0.69-3.89] | 0.265 | 0.0% |
| Caucasian population | |||||
| A vs. G | 10 | 1,692/1,465 | 2.76[2.24-3.41] | <0.001 | 0.0% |
| AG vs. GG | 10 | 1,692/1,465 | 3.10[2.48-3.88] | <0.001 | 0.0% |
| AA vs. GG | 10 | 1,692/1,465 | 1.71[0.63-4.65] | 0.294 | 0.0% |
| AG/AA vs. GG | 10 | 1,692/1,465 | 3.06[2.46-3.82] | <0.001 | 0.0% |
| AA vs. AG/GG | 10 | 1,692/1,465 | 1.46[0.54-3.97] | 0.460 | 0.0% |
| Asian population | |||||
| A vs. G | 3 | 343/303 | 1.70[0.98-2.93] | 0.058 | 70.3% |
| AG vs. GG | 3 | 343/303 | 1.56[0.86-2.84] | 0.144 | 41.4% |
| AA vs. GG | 3 | 343/303 | 2.45[0.44-13.57] | 0.305 | 46.2% |
| AG/AA vs. GG | 3 | 343/303 | 1.64[0.58-4.63] | 0.347 | 60.6% |
| AA vs. AG/GG | 3 | 343/303 | 1.88[0.10-34.58] | 0.672 | 43.6% |
(Abbreviations: OR, odds ratio; 95%CI, 95% confidence interval; TNF-α, Tumor necrosis factor-α)