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(a) A comparison of the average largest hydrophobic patch area given by RosettaDesign-SR, RosettaDesign, Liang-Grishin, and EGAD with that given by wild-type proteins. (b) A comparison of the total solvent-accessible surface area (ASA) for all residues in a protein normalized by their maximum possible total solvent-accessible surface area for the four programs and wild type.
